Welcome to RevoluGen
To sequence DNA/RNA, often referred to as the blueprint for life, the first step in any laboratory is Nucleic Acid Isolation and Purification (NAIP). The current market for NAIP kits is $2.7 billion per year of which Thermo Fisher and QIAGEN are among the market leaders. In recent months RevoluGen has been able to show that it has a disruptive technology breakthrough in this NAIP market with its lead product called Fire Monkey. Recent external validation has shown that Fire Monkey is twice as good as and takes a tenth of the time to perform as its closest competitor. To compete in this market, RevoluGen has started negotiations with potential licensing partners to market Fire Monkey.
RevoluGen was founded in 1998 by Dr Stephen Minter PhD, the inventor of the home digital pregnancy test. Dr Minter has filed over seventy patents and was the founder of Tepnel Life Sciences which was sold to GenProbe Corporation in 2010 for $155 million. In 2016 a new management team, led by former Nomura’s Healthcare & Technology group, Pieter Mulier, Dr. Erling Refsum and Alex Kaye (ex-Euroconsult) joined and successfully restructured RevoluGen to the next stage whilst raising £2.5 million.
RevoluGen’s business is to conduct research into the building blocks of life such as DNA and RNA. Discoveries about these DNA and RNA molecules are important as these molecules hold the blueprint of how to build the body and offer much promise for new disease treatments and healthy cures.
RevoluGen has technology that is genuinely ground breaking and will prove highly disruptive to the whole molecular diagnostics industry. The lead Fire Monkey product basically rapidly extracts more, long-fragments of intact-DNA from cells than the competition. A follow-up technology called Fire Wolf, rapidly identifies bacteria very accurately.
Fire Monkey is a DNA extraction kit that rapidly isolates long-fragments of intact-DNA from cells. The Fire Monkey extracted fragments of DNA are twice as long as the longest fragments extracted by the established competition and extracted in a tenth of the time.
Having pure and intact long fragments of DNA improves the accuracy of long-read DNA sequencing and fast extractions also improve laboratory capacity.
Fire Monkey’s key advantage is that it can extract DNA fragments from cells within one hour, with DNA lengths of over 165,000 base pairs. This is much better than the competition and has now been validated by independent third party analysis on a femtopulse measuring device.
Fire Monkey’s main competitive advantage is that better quality input material will always optimise the output result.
The following schematic illustrates the scale of the benefit that Fire Monkey offers laboratories over the competition. Laboratory productivity is improved by speed and data accuracy is improved by the availability of long read sequences.
NAIP market comparison – procedural time vs base pair length – longer and faster
Fire Wolf is RevoluGen’s second product
The Fire Wolf platform is an adjustable bacterial diagnostic RNA based chemistry test that can be designed for the accurate identification of any individual bacteria. The Fire Wolf test is fast, as it completes within a half hour, is highly accurate, as it can spot a single base pair difference between bacteria and is cost effective, as each test can be multiplexed to do many tests at the same time all in the same test tube. These features all combine to provide opportunities to generate panels of tests for whole groups of bacteria in the $2.2bn molecular diagnostics market. Fire Wolf may also eventually challenge many parts of the $17bn global infectious disease testing market. The initial target for Fire Wolf is to develop the world’s first test panel able to diagnose the whole Neisseria genus of bacteria.
Strategy for RevoluGen
Our strategic plan is relatively simple, the 2 core products are to be out-licensed. The Fire Monkey product will probably go to one big distributor/supplier on an exclusive basis within this year. RevoluGen has a Low cap-ex / Low op-ex commercialisation model that will utilise the established networks of manufacturing, marketing and distribution partners so that RevoluGen can concentrate on its R&D expertise.
Fire Monkey is RevoluGen’s superior Nucleic Acid Isolation and Purification (NAIP) kit. Reading the genetic code perfectly requires long strands of DNA as starting material. The purer and longer the DNA we can extract from cells, the faster we can revolutionize rapid molecular diagnostics to combat disease.
Fire Wolf is RevoluGen’s rapid and highly accurate platform for identifying bacteria. Fire Wolf reads down to a single base pair difference between bacterial 16S sequences and lends itself to being easily multiplexed. Each bacterial test version of Fire Wolf can be designed starting from just a digital sequence.